The phrase "are the very picture of" implies that someone or something perfectly embodies a particular trait, characteristic or image. The antonyms for this phrase would be "are the opposite of," "fall short of," or "are the furthest thing from." Using these antonyms would suggest that the subject being described does not accurately represent the intended trait or image. For example, "She is the opposite of calm" implies that the person is not at all calm or relaxed. Similarly, "He falls short of being trustworthy" implies that the person is not entirely reliable or honest.